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A randomized controlled pilot study of continuous glucose monitoring and flash glucose monitoring in people with Type 1 diabetes and impaired awareness of hypoglycaemia

Aim Hypoglycaemia in Type 1 diabetes is associated with mortality and morbidity, especially where awareness of hypoglycaemia is impaired. Clinical pathways for access to continuous glucose monitoring (CGM) and flash glucose monitoring technologies are unclear. We assessed the impact of CGM and flash glucose monitoring in a high-risk group of people with Type 1 diabetes. Methods A randomized, non-masked parallel group study was undertaken. Adults with Type 1 diabetes using a multiple-dose insul...


Utility of HbA1c and fasting plasma glucose for screening of Type 2 diabetes: a meta-analysis of full ROC curves

Aims There is still debate on the optimal threshold for population-based screening of diabetes (diagnosed by the oral glucose tolerance test) using tests like HbA1c or fasting plasma glucose. Meta-analyses provide meaningful input in such situations. The aim of this article is to perform a meta-analysis that includes the complete information reported in the individual studies of two existing systematic reviews. Methods We screened the individual studies from two systematic reviews and reconstr...


Predictors of early renal function decline in Type 1 diabetes: retinopathy

We were interested to read the recent article in Diabetic Medicine by Bjornstad etal. [1], who found that high estimated GFR (eGFR) and albumin excretion rates predicted early renal function decline in 91/308 people with Type 1 diabetes mellitus. Early renal function decline is defined as a three- to fivefold increase in annual eGFR loss compared with the normal physiology of aging (~1 ml/min/1.73m2/year). This article is protected by copyright. All rights reserved....


Insulin degludec overdose may lead to long-lasting hypoglycaemia through its markedly prolonged half-life

Background Overdose of insulin often causes long-lasting severe hypoglycaemia. Insulin degludec has the longest duration of action among the available insulin products; thus, an overdose of insulin degludec can lead to long-lasting hypoglycaemia. In the present paper, we report the case of a woman with long-lasting hypoglycaemia attributable to insulin degludec overdose and markedly prolonged insulin degludec half-life. Case report A 64-year-old woman with Type 2 diabetes receiving insulin the...


Emerging adulthood and Type 1 diabetes: insights from the DAWN2 Study

Aims To compare clinical, psychological, education and social variables in emerging adults (aged 1830 years) with Type 1 diabetes with their adult counterparts aged >30 years. Methods A single assessment multinational sample was surveyed as part of the larger second Diabetes Attitudes, Wishes and Needs (DAWN2) study. Participants completed a series of surveys incorporating demographic as well as clinical questions (comorbidities, hypoglycaemia) and validated self-report scales concerning psyc...


Intrapartum glycaemic control and neonatal hypoglycaemia in pregnancies complicated by diabetes mellitus: a systematic review

Aims To examine whether, in neonates of mothers with Type 1, Type 2 and gestational diabetes mellitus, in-target intrapartum glycaemic control was associated with a lower risk of neonatal hypoglycaemia compared with out-of-target glycaemic control. Methods We searched PubMed and EMBASE for all available publications, regardless of year, based on a published protocol (PROSPERO CRD42016052439). Studies were excluded if they did not report original data or were animal studies. Data were extracted...


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