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Semaglutide weight loss effects revealed in new study on obesity

New results from a phase II trial suggest that the type 2 diabetes drug semaglutide can lead to a weight loss of up to 13.8 per cent, over one year, in overweight or obese people. Researchers pitted semaglutide, a glucagon-like-peptide 1 (GLP-1) developed by Novo Nordisk, against a standard therapy combo of diet, exercise and placebo. Drugs that mimic GLP-1, or increase its levels in blood, work by stimulating insulin secretion from the pancreas and signal fullness to limit further food intake....

Man with type 2 diabetes completes epic 176-mile swim challenge

A man with type 2 diabetes has just completed an epic challenge by swimming eight times the distance of the English Channel. Mark Humfrey from Barnstaple, Devon, has raised £1,300 for Diabetes UK by racking up 11,334 lengths in his local pool as part of the charitys Swim 22 Challenge. The task gave participants three months to complete a 22-mile swim, which is the distance of the channel. But Mr Humfrey has gone above and beyond, completing the grueling mission several times over and swimmi...

Enzyme could explain link between metabolic disease and PCOS

US scientists have discovered a new link between increased male hormones and metabolic disease in people with polycystic ovary syndrome (PCOS). An enzyme that activates male hormone in the fat tissue of women with PCOS has been identified which could raise the risk of other metabolic health complications, including type 2 diabetes and fatty liver disease. Women with PCOS often have higher levels of male hormones circulating in the blood, and this study has, for the first time, showed that hormon...

Light exercise linked to insulin resistance prevention

Even small amounts of exercise could be enough to help reduce insulin resistance, the hallmark of type 2 diabetes, according to new research. The US study sheds doubt on previous findings which had suggested that enhancing the small cell structures called mitochondria, which turn glucose and fats into energy, could help alleviate some symptoms associated with a high-calorie diet. The research team from the University of Arkansas said the amount of mitochondria was not directly affected by the am...

Canakinumab reduces risk of heart disease events by targeting inflammation

Phase III results of the CANTOS heart trial have shown that a drug, previously tested in type 2 diabetes, cuts cardiovascular disease (CVD) events. The drug in question is canakinumab (ACZ885), an antibody to a pro-inflammatory cytokine molecule, called Il-1B, which is known to drive atherosclerosis. Atherosclerosis is the name for the damage to blood vessels whereby arteries become clogged. Canakinumab is the first and only agent which has shown that selectively targeting inflammation signific...

Successful eye screening programme to expand in Yorkshire

The eyes of people with diabetes are set to benefit from a screening programme which will expand across more parts of Yorkshire. The Diabetic Eye Screening Programme (DESP) has been successfully run across Wakefield and North Kirklees by Mid Yorkshire Hospitals NHS Trust for the last 15 years. But now it is set to be rolled out across Dewsbury and Batley, reaching a further 83,000 people. Over the next few years it is thought the new initiative will help more than 100,000. Speaking to the Dewsbu...