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Factors Associated With Diabetes-Specific Health-Related Quality of Life in Youth With Type 1 Diabetes: The Global TEENs Study

secstOBJECTIVE/st pOur objective was to characterize diabetes-specific health-related quality of life (D-HRQOL) in a global sample of youth and young adults with type 1 diabetes (T1D) and to identify the main factors associated w...


Risk of Severe Hypoglycemia in Type 1 Diabetes Over 30 Years of Follow-up in the DCCT/EDIC Study

secstOBJECTIVE/st pDuring the Diabetes Control and Complications Trial (DCCT), intensive diabetes therapy achieving a mean HbASUB1c/SUB of ~7% was associated with a threefold increase in the rate of severe hypoglycemia (defined a...


Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients

secstOBJECTIVE/st pMonogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately...


Toward Defining the Threshold Between Low and High Glucose Variability in Diabetes

secstOBJECTIVE/st pTo define the threshold for excess glucose variability (GV), one of the main features of dysglycemia in diabetes./p /sec secstRESEARCH DESIGN AND METHODS/st pA total of 376 persons with diabetes investigated at...


Impact of Liraglutide on Amylase, Lipase, and Acute Pancreatitis in Participants With Overweight/Obesity and Normoglycemia, Prediabetes, or Type 2 Diabetes: Secondary Analyses of Pooled Data From the SCALE Clinical Development Program

secstOBJECTIVE/st pTo describe amylase/lipase activity levels and events of acute pancreatitis (AP) in the SCALE (Satiety and Clinical Adiposity—Liraglutide Evidence in individuals with and without diabetes) weight-manageme...


Strengths, Risk Factors, and Resilient Outcomes in Adolescents With Type 1 Diabetes: Results From Diabetes MILES Youth-Australia

secstOBJECTIVE/st pDespite the challenges of living with type 1 diabetes, many adolescents achieve resilient outcomes: high engagement in self-management behaviors such as self-monitoring of blood glucose (SMBG), good quality of ...


Cardiometabolic Disease Staging Predicts Effectiveness of Weight-Loss Therapy to Prevent Type 2 Diabetes: Pooled Results From Phase III Clinical Trials Assessing Phentermine/Topiramate Extended Release

secstOBJECTIVE/st pTo assess the ability of medication-assisted weight loss to prevent diabetes as a function of the baseline weighted Cardiometabolic Disease Staging (CMDS) score./p /sec secstRESEARCH DESIGN AND METHODS/st pWe p...